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姓名: 刘亚男

性别: 女

职称: 副教授

是否博导: 否

最高学历: 研究生

最高学位: 博士

电话: 0431-85619485

邮箱: ynliu@jlu.edu.cn

详细情况

所在学科专业:

病理学与病理生理学

研究方向:

1.肿瘤基因治疗2.肿瘤耐药机制研究3.心血管疾病研究

讲授课程:

本科生:病理生理学,PBL,机能实验学,科学思维与创新

研究生:实验动物学,细胞信号转导与疾病

教育经历:

2007.09 – 2010.07,999策略白菜手机论坛,病理学与病理生理学,博士,

2005.09 – 2007.07,999策略白菜手机论坛,病理学与病理生理学,硕士,

1999.09 – 2004.07,北华大学,临床医学,学士

工作经历:

2017.9-至今,999策略白菜网站病理生理学系,副教授

2010.07 -2017.9 999策略白菜网站病理生理学系,讲师

科研项目:

科研项目(近五年)

1.李亚平,谷爽,吉林省卫生厅,sirt3对小细胞肺癌化学治疗的影响及机制,2018J061,2019.1-2021.12 3万、项目负责人

2.康劲松,刘龙。去乙酰化酶Sirtuins 3调控突变型p53阻抑肺癌机制的研究,81501982,国家自然青年基金,2016/01-2018/12、19.2万、项目负责人。

3.国家基金面上项目,基于p62调控细胞内死亡诱导复合体探讨自噬与凋亡参与卵巢癌耐药机制的研究,2017/01-2020/12,63.6万元,主要参加人。

4.吉林省教育厅,PDLIM7调控p53降解诱导肺癌细胞的凋亡作用及机制探讨、【2014】B030,2014/01-2015/12、3万元,项目负责人。

5.吉林省科技厅国际合作项目,锌联合siRNA-Mdm2-p53共表达质粒调控p53泛素化诱导前列腺癌凋亡的机制研究、20150414025GH,2015/01-2017/12、10万元、主要参加人。

科研论文:

发表科研文章(近五年)

1.Deng, Xinyue; Li, Yang; Gu, Shuang; Chen, Yingying; Yu, Bingbing; Su, Jing; Sun, Liankun; Liu, Yanan*p53 Affects PGC1 alpha Stability Through AKT/GSK-3 beta to Enhance Cisplatin Sensitivity in Non-Small Cell Lung Cancer.Frontiers in Oncology, 2020, 10: 1252.IF:4.848

2.Tang X, Li Y, Liu L, Guo R, Zhang P, Zhang Y, Zhang Y, Zhao J, Su J, Sun L, Liu Y*. Sirtuin 3 induces apoptosis and necroptosis by regulating mutant p53 expression in small‑cell lung cancer. Oncol Rep. 2020 ,43(2):591-600.IF:3.041

3.Deng, Xinyue; Wang, Quan; Cheng, Meiyu; Chen, Yingying; Yan, Xiaoyu; Guo, Rui; Sun, Liankun; Li, Yang*; Liu, Yanan*Pyruvate dehydrogenase kinase 1 interferes with glucose metabolism reprogramming and mitochondrial quality control to aggravate stress damage in cancer.Journal of Cancer, 2020, 11(4): 962-973.IF:3.565

4.Guo, Rui; Li, Yang; Xue, Yanan; Chen, Yingying; Li, Jiuling; Deng, Xinyue; Su, Jing; Liu, Yanan*; Sun, Liankun*SIRT3 increases cisplatin sensitivity of small-cell lung cancer through apoptosis Gene, 2020, 745: 144629.IF:2.984

5.Li, Jiuling; Li, Yany; Chen, Lanlan; Yu, Bingbing; Xue, Yanan; Guo, Rui; Su, Jing; Liu, Yanan*; Sun, Liankun*p53/PGC-1 alpha-mediated mitochondrial dysfunction promotes PC3 prostate cancer cell apoptosis.Molecular Medicine Reports, 2020, 22(1): 155-164. IF:1.692

6.Yuan, Danni; Zhou, Haohan; Sun, Hongyu; Tian, Rui; Xia, Meihui; Sun, Liankun*; Liu, Yanan.Identification of key genes for guiding chemotherapeutic management in ovarian cancer using translational bioinformatics.Oncology Letters, 2020, 20(2): 1345-1359. IF:2.311

7..Xue, Ya Nan; Yu, Bing Bing; Li, Jiu Ling; Guo, Rui; Zhang, Li Chao;

Sun, Lian Kun; Liu, Ya Nan*; Li, Yang*; Zinc and p53 disrupt mitochondrialbinding of HK2 by phosphorylating VDAC1 , Experimental Cell Research, 2019, 374(1): 249-258.IF:3.383

8.Ping Zhang , Yang Li , Xinyu Tang , Rui Guo , Jiuling Li , Ying Ying Chen , Hua Guo , Jing Su , Liankun Sun , Yanan Liu.Zinc enhances chemosensitivity to paclitaxel in PC‑3 prostate cancer cells,ONCOLOGY REPORTS,2017,40:2269-2277.IF:3.041

9.long liu; ping zhang; hua guo; xinyu tang; lianqin liu; jiuling li;rui guo; yangyang cai; yanan liu*; yang li* Co‑expression of murine double minute 2 siRNA and wild‑type p53 induces G1 cell cycle arrest in H1299 cells,Molecular medicine reports,2017. 16(6):9137-9142 IF:1.692,

科研论文:

发表科研文章

1.Deng, Xinyue; Li, Yang; Gu, Shuang; Chen, Yingying; Yu, Bingbing; Su, Jing; Sun, Liankun; Liu, Yanan*p53 Affects PGC1 alpha Stability Through AKT/GSK-3 beta to Enhance Cisplatin Sensitivity in Non-Small Cell Lung Cancer.Frontiers in Oncology, 2020, 10: 1252.IF:4.848

2.Tang X, Li Y, Liu L, Guo R, Zhang P, Zhang Y, Zhang Y, Zhao J, Su J, Sun L, Liu Y*. Sirtuin 3 induces apoptosis and necroptosis by regulating mutant p53 expression in small‑cell lung cancer. Oncol Rep. 2020 ,43(2):591-600.IF:3.041

3.Deng, Xinyue; Wang, Quan; Cheng, Meiyu; Chen, Yingying; Yan, Xiaoyu; Guo, Rui; Sun, Liankun; Li, Yang*; Liu, Yanan*Pyruvate dehydrogenase kinase 1 interferes with glucose metabolism reprogramming and mitochondrial quality control to aggravate stress damage in cancer.Journal of Cancer, 2020, 11(4): 962-973.IF:3.565

4.Guo, Rui; Li, Yang; Xue, Yanan; Chen, Yingying; Li, Jiuling; Deng, Xinyue; Su, Jing; Liu, Yanan*; Sun, Liankun*SIRT3 increases cisplatin sensitivity of small-cell lung cancer through apoptosis Gene, 2020, 745: 144629.IF:2.984

5.Li, Jiuling; Li, Yany; Chen, Lanlan; Yu, Bingbing; Xue, Yanan; Guo, Rui; Su, Jing; Liu, Yanan*; Sun, Liankun*p53/PGC-1 alpha-mediated mitochondrial dysfunction promotes PC3 prostate cancer cell apoptosis.Molecular Medicine Reports, 2020, 22(1): 155-164. IF:1.692

6.Yuan, Danni; Zhou, Haohan; Sun, Hongyu; Tian, Rui; Xia, Meihui; Sun, Liankun*; Liu, Yanan.Identification of key genes for guiding chemotherapeutic management in ovarian cancer using translational bioinformatics.Oncology Letters, 2020, 20(2): 1345-1359. IF:2.311

7..Xue, Ya Nan; Yu, Bing Bing; Li, Jiu Ling; Guo, Rui; Zhang, Li Chao;

Sun, Lian Kun; Liu, Ya Nan*; Li, Yang*; Zinc and p53 disrupt mitochondrialbinding of HK2 by phosphorylating VDAC1 , Experimental Cell Research, 2019, 374(1): 249-258.IF:3.383

8.Ping Zhang , Yang Li , Xinyu Tang , Rui Guo , Jiuling Li , Ying Ying Chen , Hua Guo , Jing Su , Liankun Sun , Yanan Liu.Zinc enhances chemosensitivity to paclitaxel in PC‑3 prostate cancer cells,ONCOLOGY REPORTS,2017,40:2269-2277.IF:3.041

9.long liu; ping zhang; hua guo; xinyu tang; lianqin liu; jiuling li;rui guo; yangyang cai; yanan liu*; yang li* Co‑expression of murine double minute 2 siRNA and wild‑type p53 induces G1 cell cycle arrest in H1299 cells,Molecular medicine reports,2017. 16(6):9137-9142 IF:1.692,

著作教材:


获奖情况:

不限年度(例:主要完成人、项目名称及编号、奖励级别、获奖年度)

1.苏静、孙连坤、刘亚男、康劲松、李亚平、李扬、于慧美、沈璐妍,干预线粒体网络逆转肿瘤耐药机制研究,2019Z20004,吉林省科学技术奖,二等奖,2019

2.苏静,刘亚男,第五届全国老员工基础医学创新论坛暨实验设计大赛,NDC18A110000272,二等奖,2018

3.刘亚男,999策略白菜手机论坛“学风建设表彰”获“优秀指导教师”称号,2018

4.张勇,刘亚男。首届全国青年教师机能学实验机能大赛,CAP2017A117,二等奖,国家级,2017

5.刘亚男,张勇,李杨。第一届中国医学高校创新性机能实验设计大赛,NDC17A110002441,三等奖,国家级,2017

6.李扬,顾俊莲,汲坤,江涛,王波,刘亚男 减毒沙门氏菌携带共表达siRNA-mdm2与p53质粒抗前列腺癌的实验研究 吉林省自然科学学术成果奖二等奖2014

社会兼职:

中国实验动物学会实验动物模型鉴定与评价工作委员会委员

中国微循环学会转化医学专业委员会委员

人民卫生出版社中国医学教育题库编写委员会编委

吉林省病理生理学会理事

中国病理生理学会会员

《中国细胞生物学学报》审稿人

中国细胞生物学学会会员

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